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Clicking on the donut icon will load a page at altmetric. Find more information on the Altmetric Attention Score and how the score is calculated. Cancer nanotechnology research, with an emphasis on polymer chemistry, has focused on the development of multifunctional nanoscale devices that interface with biological systems.

Synthetic Polymer-Based Nanoparticles: Intelligent Drug Delivery Systems

Polymer-based drug delivery systems DDS have now been established as promising nanovehicles for the diagnosis and treatment of cancer. Effective DDS encapsulate anticancer therapeutics and include hydrophilic coatings that ensure biocompatibility and colloidal stability. Ideally, delivery of small molecule anticancer drugs in nanosized carriers enables the selective delivery of a therapeutically relevant payload to tumor cells.


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  8. The rapid growth of tumors results in new vasculature with irregularly aligned endothelial cells as well as poor lymphatic drainage; this in turn facilitates extravasation enhanced permeation and accumulation of nanocarriers retention within tumor tissues. The process called the enhanced permeation and retention effect EPR allows for passive targeting of polymer-based DDS to tumors, thus minimizing undesired side effects and maximizing drug efficacy common to small drugs. Once at the target site the DDS could release their cargo in the tumor interstitium or following endocytosis into cells of the solid tumor.

    Yet, it has been found that the delivery of small molecule drugs in DDS is complex given that their pharmacokinetics, biodistribution, intracellular trafficking, and drug release are difficult to predict.

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    In recent years significant efforts have been made in polymer-based DDS research, and several promising self-assembled nanocarriers have reached clinical development. Despite these tremendous advances, additional fundamental and applied research is needed to achieve more precise control over the properties and performance of polymer-based DDS. This special issue is composed of a total of 15 papers that largely emanated from abstracts that were submitted to the symposium from renowned research groups in Canada and abroad.

    Eleven original research articles are also included in this special issue and cover a diverse range of topics.

    New Polymers for Drug Design and Delivery | Cornell Research

    Four contributions describe the development of new block copolymer-based micelles exhibiting stimulus-responsive enhanced or on-demand release of encapsulated therapeutics. Four contributions describe the exploration of the general aspects of drug delivery on self-assembled micellar systems.

    Natural polymers have been utilized extensively in food, pharmaceuticals, cosmetics, textiles, oil drilling and paint industries. Their non-toxic and inexpensive attributes readily enhance their commercial acceptability and make them potent agents in lieu of synthetic polymers. This book explores the opportunistic utility of natural polymers in developing effective drug delivery systems and provides a comprehensive and up-to-date analysis of their source, chemical structure and mechanism of action.

    clublavoute.ca/somel-dating-app-de.php Covering novel polymers for drug delivery - in particular extracts from plants, microorganisms and proteins, as well as water soluble and water insoluble biodegradable polymers - it presents an encyclopaedic overview of natural polymers': - quintessential roles in binding drugs towards enhancing bioavailability - modification and derivatization for targeted delivery - role as active drugs Natural Polymers for Drug Delivery is an invaluable resource for researchers, students and industrial scientists in the fields of biochemistry, chemistry, pharmacology and food science.

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